Resolving genetic heterogeneity in cancer

Resolving Terminological Heterogeneity In Ontologies

A system that enables interoperation among information sources using ontologies needs to resolve the terminological differences between ontologies. In this work, we present several methods that we have designed to match terms used in different ontologies. We have implemented two methods based on linguistic similarities of terms used in the ontologies. The first looks up a dictionary or semantic...

Resolving Ontological Heterogeneity in the KRAFT Project

KRAFT is an agent architecture for the integration of heterogeneous information systems. The focus in KRAFT is on the integration of knowledge in the form of constraints. In this article we describe the architecture from an ontological perspective. We start by introducing the agent architecture and illustrate its application in the telecommunication-network design. We then describe how we asses...

Resolving Astrocyte Heterogeneity in the CNS

Astrocytes play essential roles in nearly all aspects of brain function from modulating synapses and neurovasculature to preserving appropriate extracellular solute concentrations. To meet the complex needs of the central nervous system (CNS), astrocytes possess highly specialized properties that are optimized for their surrounding neural circuitry. Precisely how these diverse astrocytes types ...

Resolving Keyword Abbreviation Heterogeneity Using Gene Matching

Genetic heterogeneity in breast cancer: the road to personalized medicine?

More women die from breast cancer across the world today than from any other type of malignancy. The clinical course of breast cancer varies tremendously between patients. While some of this variability is explained by traditional clinico-pathological factors (including patient age, tumor stage, histological grade and estrogen receptor status), molecular profiling studies have defined breast ca...